Ever since he was seven years old, Matt Horick has been dealing with strange symptoms relating to his skeletal system. He has had abnormal-looking toes, pain in his hips that appeared to have been caused by hip displasia, pain in his legs, and a strange lump on his back due to a rare disease called fibrodyplasia ossificans progressiva (FOP). A two-year-old girl named Haven Fowler gains weight at an alarming rate, has hallucinations at night, eats while sleepwalking, goes into a seizure, and temporarily stops breathing from ROHHAD syndrome, a rare diseases that affects the brain.
Every year, millions of Americans fall prey to real-life medical mysteries ailments that go undiagnosed or misdiagnosed for years. Their lives are thrown into turmoil as medical professionals struggle to understand their baffling conditions. Mystery diagnosis tells their stories. Through interviews and dramatic recreations, each medical mystery is recounted in vivid detail. Symptoms emerge, specialists are called in, but still the daily struggle continues. And then one day, because of a patients relentless pursuit of an accurate diagnosis, or a forward thinking doctor, the problem is solved and a true diagnosis given.
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