After several miscarriages, Amanda Coveler finally gives birth to a second daughter. However, she deals with fatigues; headaches; dry, dark patches on her skin; dry, brittle hair; and pain in her knees. Surprisingly, Amanda feels fine during her pregnancies, but unwell when she’s not pregnant. Eventually, she learns that she has Hashimoto’s disease, an autoimmune disease that attacks her thyroid gland. Anne Hummel, a happy mother of four, suddenly develops excruciating headaches and sinus infections, a runny nose, a metallic taste in her mouth, blurred vision, and the inability to move on her own. Her doctors believed she simply has sinusitis, but eventually, one doctor finds out that Anne actually has a cerebrospinal fluid (CSF) leak.
Every year, millions of Americans fall prey to real-life medical mysteries ailments that go undiagnosed or misdiagnosed for years. Their lives are thrown into turmoil as medical professionals struggle to understand their baffling conditions. Mystery diagnosis tells their stories. Through interviews and dramatic recreations, each medical mystery is recounted in vivid detail. Symptoms emerge, specialists are called in, but still the daily struggle continues. And then one day, because of a patients relentless pursuit of an accurate diagnosis, or a forward thinking doctor, the problem is solved and a true diagnosis given.
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